Title: Modeling the Myosin Heavy-Chain-Associated RNA Transcript Gene Regulatory Network

Abstract: A key marker of heart disease is the shift in the ratio between the expression of myosin heavy chain 6 (Myh6 and myosin heavy chain 7 (Myh7). Healthy adult hearts exhibit a higher expression of Myh6, while adult hearts in heart failure exhibit a higher expression of Myh7. Studies have shown that a long noncoding RNA called Mhrt is a key factor in the regulation of both Myh6 and Myh7. The purpose of this project is to model the interaction between these three genes to gain a better understanding of the switch between Myh6 and Myh7. We break the model down into two parts - the relationship between Myh6 and Mhrt and the relationship between Myh6 and Mhrt - before combining the two to create a comprehensive model for the gene regulatory network.