HHP:1000 Obesity Epidemic: Medical and Socioeconomic Consequences (First-Year Seminar)
HHP:4480 Introduction to Human Pharmacology
HHP:6480 Advanced Human Pharmacology
HHP:4460 Cardiovascular Physiology
HHP:6460 Advanced Cardiovascular Physiology
Since the start of my research career in the early 90s my interest has been the role of the autonomic nervous system in maintaining homeostasis in response to physiologic perturbations and in diseases. Early on, I studied sympathetic modulation of cardiac and vascular function using sympathetic nerve activity recordings and electrical stimulation of peripheral sympathetic nerves or hypothalamic brain regions controlling autonomic function in conscious rats. More recently I also focused on the role of the parasympathetic nervous system and developed miniaturized nerve stimulators that can be chronically implanted in rats and mice. Using these stimulators we investigated the differential effects of afferent vs. efferent vagal nerve stimulation on glucose metabolism and in our most recent study we also used the implantable nerve stimulators in a chronic protocol to investigate the role of the parasympathetic nervous system in preventing cardiovascular end-organ damage in severely hypertensive rats.
Stauss HM. Differential Hemodynamic and Respiratory Responses to Right and Left Cervical Vagal Nerve Stimulation in Rats. Physiol. Reports, 2017 in press.
Rana S, Pugh PC, Katz E, Stringfellow SA, Lin CP, Stauss HM, White CR, Kerman IA. Independent Effects of Early-Life Experience and Trait Aggression on Baseline Cardiovascular Function. Am. J. Physiol. Regulatory, Integrative, and Comparative Physiology, 311(2):R272-R286, 2016.
Chapleau MW, Rotella DL, Reho JJ, Rahmouni K, and Stauss HM. Chronic Vagal Nerve Stimulation Prevents High-Salt Diet-Induced Endothelial Dysfunction and Aortic Stiffening in Stroke-Prone Spontaneously Hypertensive Rats. Am. J. Physiol.: Heart and Circ. Physiol., 311(1):H276-H285, 2016.
Stauss HM and Bjelakovic B. Re: Pediatric Hypertension and Cardiac Hypertrophy. Curr Hypertens Rep 18(1):5, 2016.
Pierce GL, Harris SA, Seals DR, Casey DP, Barlow PB, and Stauss HM. Estimated aortic stiffness is independently associated with cardiac baroreflex sensitivity in humans: role of ageing and habitual endurance exercise. J Hum Hypertens, 30(9):513-520, 2016.
Meyers EE, Kronemberger A, Lira V, Rahmouni K, and Stauss HM. Contrasting effects of afferent and efferent vagal nerve stimulation on insulin secretion and blood glucose regulation. Physiological reports 4(4):1-9, 2016.
Stauss HM. Heart Rate Variability – Just a Surrogate for Mean Heart Rate? Hypertension. 64(6):1184-1186. 2014.
Linder JR, Stauss HM, Gindes H, Pierce GL, Von Bergen NH, Haynes WG, and Fiedorowicz JG. Finger volume pulse waveforms facilitate reliable assessment of heart rate variability, but not blood pressure variability or baroreflex function. BMC Cardiovascular Disorders. 14:180, 2014.
Xie Z, Su W, Liu S, Zhao G, Esser K, Schroder EA, Lefta M, Stauss HM, Guo Z, and Gong MC. Smooth-muscle BMAL1 participates in blood pressure circadian rhythm regulation. J Clin Invest, 125(1):324-336, 2014.
Pierce GL, Casey DP, Fiedorowicz JG, Seals DR, Curry TB, Barnes JN, Wilson DR, and Stauss HM. Aortic Pulse Wave Velocity and Reflecting Distance Estimation from Peripheral Waveforms in Humans: Detection of Age- and Exercise Training-Related Differences. Am. J. Physiol. Heart Circ. Physiol. 305(1):H135-H142; 2013.
Hilzendeger A, Cassell M, Davis D, Stauss HM, Mark AL, Grobe J, and Sigmund CD. Angiotensin AT1a Receptors in the Subfornical Organ are Required for DOCA-Salt Hypertension. Hypertension 61(3):716-722; 2013.
Stauss HM and Rarick KR. Overestimation of mean heart rate by the arithmetic average of beat-by-beat sampled heart rate values. The Open Hypertension Journal 4:33-36, 2011.
Stauss HM, Rarick KR, Leick KM, Burkle JW, Rotella DL, and Anderson MG. Non-invasive assessment of vascular structure and function in conscious rats based on in vivo imaging of the albino iris. Am J Physiol Regul Integr Comp Physiol 300:R1333-R1343, 2011.
Bhatia V, Rarick KR, Stauss HM. The effect of data sampling rate on the accuracy of indices for heart rate and blood pressure variability and baroreflex function in resting rats and mice. Physiol. Meas. 31(9):1185-1201, 2010.
Schwimmer H, Stauss HM, Abboud F, Nishino S, Mignot E, Zeitzer JM. Effects of sleep on the cardiovascular and thermoregulatory systems: a possible role for hypocretins. J. Appl. Physiol. 109(4):1053-1063, 2010.