Vitor Lira

You are here

Vitor Lira
Associate Professor
Area:
Human Physiology
Specialization:
Muscle biology,exercise physiology, substrate metabolism, proteostasis, gene regulation
End Degree:
PhD in Exercise Physiology
Institution:
University of Florida
Office:
4324 PBDB, N424 FH
Phone:
319-335-6966
Email: Laboratory:
Muscle Biology & Metabolism Laboratory
Lab Website:

Lab:  Muscle Biology & Metabolism  and FOE Diabetes Research Center

Post-doctoral Fellowship 

Robert M. Berne Cardiovascular Research Center, University of Virginia

Courses Taught

  • HHP:4510 Energy Metabolism in Health and Disease
  • HHP:6510 Advanced Energy Metabolism in Health and Disease
  • HHP:4410 Exercise Physiology
  • HHP:6410 Advanced Exercise Physiology
  • HHP:4130 Skeletal Muscle Physiology
  • HHP:6130 Advanced Skeletal Muscle Physiology
  • HHP:4500 Undergraduate Independent Study
  • HHP:6000 Graduate Research
  • HHP:6400 Integrative Physiology Seminar

Research Interests

Metabolic and contractile dysfunctions in skeletal and cardiac muscles are present in several conditions that become more prevalent with aging (e.g., sarcopenia, cardiovascular diseases, neurodegenerative diseases, cancer, obesity and diabetes) reducing quality of life and increasing mortality. Impaired proteostasis leading to reduced proteome quality is a common feature of these conditions contributing to cellular dysfunction. Although our understanding of the different processes involved in the maintenance of proteostasis continues to evolve, the coordinated regulation of these mechanisms in contractile tissues remains poorly understood. Our overall research goal is to determine the cellular and molecular mechanisms that become compromised in these conditions thereby identifying novel targets for therapy. Deciphering the intracellular and cross-tissue pathways responsible for the exercise-mediated improvement of the skeletal and cardiac muscle proteomes is also of major interest. We conduct functional studies combining unbiased approaches (e.g., proteomics, metabolomics) with molecular biology and mouse genetics.

 

Recent Select Publications

Full list of published work in NCBI

Sousa LGO, Marshall AG, Norman JE, Fuqua JD, Lira VA, Rutledge JC, Bodine SC. The effects of diet composition and chronic obesity on muscle growth and function. J Appl Physiol (1985). 2021 Jan 1;130(1):124-138. doi: 10.1152/japplphysiol.00156.2020. Epub 2020 Nov 19. PubMed PMID: 33211595.

Zhang Z, Qian Q, Li M, Shao F, Ding WX, Lira VA, Chen SX, Sebag SC, Hotamisligil GS, Cao H, Yang L. The unfolded protein response regulates hepatic autophagy by sXBP1-mediated activation of TFEB. Autophagy. 2020 Jul 15;:1-15. doi: 10.1080/15548627.2020.1788889. [Epub ahead of print] PubMed PMID: 32597296.

Yamada M, Hokazono C, Tokizawa K, Marui S, Iwata M, Lira VA, Suzuki K, Miura S, Nagashima K, Okutsu M. (2019) Muscle-derived SDF-1α/CXCL12 modulates endothelial cell proliferation but not exercise training-induced angiogenesis. Am J Physiol Regul Integr Comp Physiol. 317(6):R770-779.

Fuqua JD, Mere CP, Kronemberger A, Blomme J, Bae D, Turner KD, Harris MP, Scudese E, Edwards M, Ebert SM, de Sousa LGO, Bodine SC, Yang L, Adams CM, Lira VA. (2019) ULK2 is essential for degradation of ubiquitinated protein aggregates and homeostasis in skeletal muscle. FASEB J. 33(11):11735-11745.

Yamada M, Iwata M, Warabi E, Oishi H, Lira VA, Okutsu M. (2019) p62/SQSTM1 and Nrf2 are essential for exercise-mediated enhancement of antioxidant protein expression in oxidative muscle. FASEB J. 33(7), 8022-8032.

Stauss HM, Stangl H, Clark KC, Kwitek AE, Lira VA. (2018) Cervical vagal nerve stimulation impairs glucose tolerance and suppresses insulin release in conscious rats. Physiol Rep. Dec;6(24):e13953.

Tsushima, K., Bugger, H., Wende, A. R., Soto, J., Jenson, G. A., Tor, A. R., McGlauflin, R., Kenny, H. C., Zhang, Y., Souvenir, R., Hu, X. X., Pereira, R. O., Lira, V. A., Spitzer, K. W., Sharp, T. L., Shoghi, K. I., Sparagna, G. C., Rog-Zielinska, E. A., Kohl, P., Khalimonchuk, O., Schaffer, J. E., Abel, E. D. (2018). Mitochondrial reactive oxygen species in lipotoxic hearts induce post-translational modifications of AKAP121, DRP1, and OPA1 that promote mitochondrial fission. Circulation Research 122(1), 58-73.

Laker, R., Drake, J., Wilson, R., Lira, V. A., Lewellen, B. M., Ryall, K. A., Fisher, C. C., Zhang, M., Saucerman, J. J., Goodyear, L. J., Kundu, M., Yan, Z. (2017). Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy. Nature Communications, 8(1), 548. 

Boland, L., Burand, T., Brown, A. J., Boyt, D., Lira, V. A., Ankrum, J. A. (2017). IFN-gamma and TNF-alpha pre-licensing protects mesenhymal stromal cells from the pro-inflammatory effects of palmitate. Molecular Therapy 7(26), 860-873. 

Meyers, E. E., Kronemberger, A., Lira, V., Rahmouni, K., Stauss, H. M. (2016). Contrasting effects of afferent and efferent vagal nerve stimulation on insulin secretion and blood glucose regulation. Physiological Reports, 4(4), e12718.

Call JA, Donet J, Martin KS, Sharma AK, Chen X, Zhang J, Cai J, Galarreta CA, Okutsu M, Du Z, Lira V A, Zhang M, Mehrad B, Annex BH, Klibanv AL, Laubach RP, Pierce SM, Yan Z. (2017). Muscle-derived extracellular superoxide dismutase inhibtis endothelial activation and protects against multiple organ dysfunction syndrome in mice. Free Radical Biology and Medicine, 113, 212-223. 

Turner J, Lira V, Brum P. (2017). New insights into the benefits of physical activity and exercise for aging and chronic disease. Oxidative Medicine and Cellular Longevity, 2017(2503767). 

Yan Z, Kronemberger H M, Blomme J, Call JA, Caster, HM, Pereira RO, Zhao H, Melo VU, Laker RC, Zhang M, Lira VA. (2017). Exercise leads to unfavorable cardiac remodeling and enhanced metabolic homeostasis in obese mice with cardiac and skeletal muscle autophagy deficiency. Scientific Reports, 7(1), 7894. 

Klionsky DJ, Abdelmohsen K, Abe A,..., Lira, VA, et al. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12(1):1-222.

Ebert SM, Dyle MC, Bullard SA, Dierdorff JM, Murry DJ, Fox DK, Bongers KS, Lira VA, Meyerholz DK, Talley JJ, Adams CM. (2015) Identification and small molecule inhibition of an activating transcription factor 4 (ATF)-dependent pathway to age-related skeletal muscle weakness and atrophy. J Biol Chem 290(42):25497-511.

Chao H, Li H, Grande R, Lira V, Yan Z, Harris TE, Li C. Involvement of mTOR in type 2 CRF receptor inhibition of insulin signaling in muscle cells. Mol Endocrinol 29(6):831-41.

Cohen TJ, Choi MC, Kapur M, Lira VA, Yan Z, Yao TP. (2015) HDAC4 regulates muscle fiber type-specific gene expression programs. Mol Cells 38(4):343-48.

Lira VA. Exercise-induced cardioprotection: more to k“NO”w. (2015) Cardiology 130(3):172-174.

Call JA, Chain KH, Martin KS, Lira VA, Okutsu M, Zhang M, Yan Z. (2015) Enhanced skeletal muscle expression of EcSOD mitigates streptozotocin-induced diabetic cardiomyopathy by reducing oxidative stress and aberrant cell signaling. Circ Heart Fail 8(1):188-97.

Okutsu M, Call JA, Lira VA, Zhang M, Donet JA, French BA, Martin KS, Peirce-Cottler SM, Rembold CM, Annex BH, Yan Z. (2014) Extracellular superoxide dismutase ameliorates skeletal muscle abnormalities, cachexia, and exercise intolerance in mice with congestive heart failure. Circ Heart Fail 7(3):519-30.

Okutsu M, Lira VA, Higashida K, Peake J, Higuchi M, Suzuki K. (2014) Corticosterone accelerates atherosclerosis in the apolipoprotein E-deficient mouse. Atherosclerosis 232(2):414-9.

Lira VA, Okutsu M, Zhang M, Greene NP, Laker RC, Breen DS, Hoehn KL, Yan Z. (2013) Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance. FASEB J 27(10):4184-93.

Yan Z, Lira VA, Greene NP. (2012) Exercise training-induced regulation of mitochondrial quality. Exerc Sport Sci Rev 40(3):159-64.

Yan Z, Okutsu M, Akhtar YN, Lira VA. (2011) Regulation of exercise-induced fiber type transformation, mitochondrial biogenesis, and angiogenesis in skeletal muscle. J Appl Physiol 110(1):264-74.

Lira VA, Brown DL, Lira AK, Kavazis AN, Soltow QA, Zeanah EH, Criswell DS. (2010) Nitric oxide and AMPK cooperatively regulate PGC-1 in skeletal muscle cells. J Physiol 588(Pt 18):3551-66.

Lira VA, Benton CR, Yan Z, Bonen A. (2010) PGC-1{alpha} regulation by exercise training and its influences on muscle function and insulin sensitivity. Am J Physiol Endocrinol Metab 299(2):E145-61.

Lira VA, Soltow QA, Long JH, Betters JL, Sellman JE, Criswell DS. (2007) Nitric oxide increases GLUT4 expression and regulates AMPK signaling in skeletal muscle. Am J Physiol Endocrinol Metab 293(4):E1062-8.

Grant Funding

National Institutes of Health, NIA  1R56AG063820 - 01A1: Lira (PI)                            9/20/20 – 9/19/21
Molecular regulation of protein turnover in skeletal muscle

FOEDRC, UI, Development Grant: Lira (PI)                                                                  7/1/19 – 6/30/21
Leveraging the selective degradation of ubiquitinated protein aggregates to improve muscle function